Association between time to target mean arterial pressure and 90-day mortality in septic shock: a post hoc analysis of the OPTPRESS trial
Primary result · 90-day mortalityResult — go to the resultAdjusted odds ratio 1.48 95% CI 1.11–1.98Authors' conclusion
In this secondary analysis of the OPTPRESS trial, delayed attainment of the randomized lower-bound MAP target was associated with higher 90-day mortality.
Study context
- Population
- Patients with septic shock in the OPTPRESS trial (mean arterial pressure (MAP) target 80 mmHg high-target arm; 65 mmHg low-target arm)516 enrolled
- Participants
- 476 patients
- Comparison
- Time to target MAP categories vs <1 h
- Primary endpoint
- 90-day all-cause mortality
- Follow-up
- 90 days
Methodological detailspost hoc, doubly robust estimation, complete-case cohort
- Post hoc
- Doubly robust estimation
- Complete-case cohort
Primary result
90-day mortality
Adjusted odds ratio
1.48
95% CI 1.11–1.98
P = 0.008
≥12 h vs <1 h
aOR 1.48 (95% CI 1.11–1.98); P = 0.008
As reported in the abstract
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| 90-day mortality per 1-h increase in TTT-MAP (continuous; patients reaching target within 24 h) | aOR 1.025 (95% CI 0.972–1.082) | P = 0.362 | |
| 90-day mortality, Cox model: prolonged TTT-MAP (≥12 h or unreached) vs early attainment (<12 h and reached) | aHR 3.24 (95% CI 2.19–4.80) | P < 0.001 | |
| 0.20.5125Ratio (log scale) |
Original publication
Association between time to target mean arterial pressure and 90-day mortality in septic shock: a post hoc analysis of the OPTPRESS trial. Ann Intensive Care. Published 14 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →