Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial
Primary resultResult — go to the resultRisk difference 10.7 95% CI 2.6–18.9- terminated early after interim analysis
- Trial terminated early on the basis of interim analysis results suggesting harm of the high-target strategy
Authors' conclusion
Among older patients with septic shock, high-target MAP significantly increased mortality compared with standard care.
Study context
- Population
- Patients aged ≥ 65 years with septic shock admitted to ICU, 29 hospitals in Japan
- Participants
- 518 patients · 29 hospitals
- Comparison
- High-target mean arterial pressure (MAP) vs control
- Highn = 258
- Controln = 260reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, pragmatic, open-label
- Multicentre
- Pragmatic
- Open-label
Primary result
As reported in the abstract
Risk difference
10.7
95% CI 2.6–18.9
Events by treatment group
High vs Control
risk difference 10.7 (95% CI 2.6–18.9)
Secondary outcomes
RRT-free days · 28 days
- Shorter in the high-target group
Subpopulations, incl. known chronic hypertension (subgroup)
- No clinical benefits for any outcome in any subpopulation
Original publication
Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med. Published 13 May 2025. doi:10.
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