Perioperative medicine & outcomes
Association between total fluid volume and postoperative morbidity after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Main finding · CCI at day 28 and its association with total day-0 fluid volumeResult — go to the resultOdds ratio 1.12 95% CI 1.06–1.19Authors' conclusion
In patients undergoing CRS with HIPEC, total fluid balance on the day of surgery-including intraoperative and immediate postoperative fluids-was associated with postoperative morbidity at day 28.
Study context
- Population
- Patients undergoing CRS with HIPEC, January 2019–June 2024
- Participants
- 132 patients
- Comparison
- Perioperative fluid volume by Comprehensive Complication Index (CCI) tertile
- Outcome
- Comprehensive Complication Index (CCI)
- Follow-up
- Day 28
Methodological detailssingle-centre, multivariable analysis
- Single-centre
- Multivariable analysis
Main finding
As reported in the abstract
CCI at day 28 and its association with total day-0 fluid volume
Odds ratio
1.12
95% CI 1.06–1.19
P < 0.001
Perioperative fluid volume by CCI tertile (first vs third)
OR 1.12 (95% CI 1.06–1.19); P < 0.001
- Median CCI at day 28 (IQR 0-31)
- 21
Observational data: associations, not effects.
Secondary outcomes
Intraoperative fluid administration by CCI tertile
P < 0.001
Total day-0 fluid administration by CCI tertile
P < 0.001
Intraoperative fluid use (all patients)
- Crystalloids used
- 132 patients, 100%
- Colloids used
- 16 patients (12%)
- Median intraoperative fluid rate, mL/kg/h (IQR 11.0-17.7)
- 13.6
Safety
At least one postoperative complication
- Patients with ≥1 complication
- 75 (57%)
Original publication
Association between total fluid volume and postoperative morbidity after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. J Clin Anesth. Published 30 May 2026. doi:10.
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