Perioperative medicine & outcomes
Early postoperative pain and 30-day complications following major abdominal surgery: a retrospective cohort study
Authors' conclusion
After major abdominal surgery, higher postoperative pain scores on day 1 are associated with an increased risk of 30-day postoperative complications.
Study context
- Population
- Patients undergoing major abdominal surgery (cytoreductive surgery and HIPEC, esophageal, liver, or pancreas surgery) at Radboud university medical center, 2014–2020randomly selected
- Participants
- 1,000 patients
- Exposure
- POD1 pain scores and 30-day complications
- Outcome
- 30-day postoperative complications (infectious, non-infectious, total, Clavien-Dindo classification)
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association of POD1 pain scores with 30-day complications (logistic regression)
Total complications, OR
1.132
95% CI 1.076 to 1.190
Clavien-Dindo classification, OR
1.131
95% CI 1.071 to 1.193
Infectious complications, OR
1.126
95% CI 1.059 to 1.196
Non-infectious complications, OR
1.079
95% CI 1.022 to 1.140
Observational data: associations, not effects.
Further findings
Complications within 30 days
- Complications
- 790
- Patients with complications
- 572
- Infectious complications
- 289 (36.7%)
- Non-infectious complications
- 501 (63.4%)
Mean time from end of surgery to complication (days)
- Difference
- P < 0.001
- Infectious, mean 6.5 days (SD 5.6)
- Non-infectious, mean 4.1 days (SD 4.7)
Original publication
Early postoperative pain and 30-day complications following major abdominal surgery: a retrospective cohort study. Reg Anesth Pain Med. Published 4 June 2024. doi:10.
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