Perioperative medicine & outcomes
Effect of Urine-guided Intraoperative Hydration on Incidence of Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei: A Randomized Trial
Primary result · AKIResult — go to the resultRelative risk 0.55 95% CI 0.33–0.89Authors' conclusion
In patients who underwent CRS and cisplatin-HIPEC for pseudomyxoma peritonei, intraoperative urine-guided hydration reduced postoperative AKI by more than 40% and was safe.
Study context
- Population
- Adults scheduled for cytoreductive surgery (CRS) and cisplatin-based hyperthermia intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritoneiall in ITT analysis
- Participants
- 168 adults
- Comparison
- Urine-guided vs routine intraoperative hydration
- Urine-guided hydrationn = 84
- Routine hydrationn = 84reference
- Primary endpoint
- Incidence of acute kidney injury (AKI) (Kidney Disease Improving Global Outcome criteria)
- Follow-up
- Within 7 days after surgery
Primary result
AKI · within 7 days
Relative risk
0.55
95% CI 0.33–0.89
P = 0.012
Events by treatment group
Urine-guided hydration vs Routine hydration
RR 0.55 (95% CI 0.33–0.89); P = 0.012
As reported in the abstract
Further findings
| Outcome | Routine hydration | RR (95% CI) | P value | |
|---|---|---|---|---|
| AKI by urine criteria (subgroup) | 35.7% | 0.60 (0.36–0.99) | P = 0.040 | |
| 0.20.5125Relative risk (log scale) |
Safety
| Outcome | Urine-guided hydration | Routine hydration | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Major complications · within 30 days | 36.9% | 56.0% | 0.66 (0.47–0.92) | P = 0.013 | |
| 0.512Relative risk (log scale) |
Adverse events
- Did not differ between groups
Original publication
Effect of Urine-guided Intraoperative Hydration on Incidence of Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei: A Randomized Trial. Anesthesiology. Published 13 August 2025. doi:10.
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