Perioperative medicine & outcomes
Impact of intraoperative desmopressin on postoperative urine output in adult cadaveric kidney transplantation: a single-centre retrospective cohort study
Main finding · Immediate postoperative UOPResult — go to the resultDifference 0.6 mL·kg-1Authors' conclusion
Intraoperative desmopressin in adult cadaveric kidney transplant recipients was associated with reduced urine output in the postoperative period without any significant hemostatic benefit.
Study context
- Population
- Adults receiving a cadaveric kidney transplant, tertiary care academic hospital in Baltimore, MD, US, January 2016 to December 2022
- Participants
- 938 adults
- Exposure
- Intraoperative desmopressin vs no desmopressin
- Desmopressinn = 359
- Outcome
- Immediate postoperative UOP (mL·kg-1)
- Follow-up
- Immediate postoperative period
Methodological detailssingle-centre, multivariable linear regression
- Single-centre
- Multivariable linear regression
Main finding
Immediate postoperative UOP
Difference
0.6 mL·kg-1
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (mL·kg-1) |
|---|---|
| UOP at 12 hr postoperativelyReduction | 3 |
| UOP at 24 hr postoperativelyReduction | 6 |
Estimated blood loss (EBL)
- Desmopressin associated with a slightly higher EBL
Postoperative hemoglobin
- Dilutional reduction in postoperative hemoglobin
Original publication
Impact of intraoperative desmopressin on postoperative urine output in adult cadaveric kidney transplantation: a single-centre retrospective cohort study. Can J Anaesth. Published 21 March 2025. doi:10.
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