Hemodynamics, fluids & transfusion
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis
Pooled result · DGFResult — go to the resultRelative risk 0.82 95% CI 0.71–0.94Authors' conclusion
Balanced lower-chloride solutions significantly reduce the occurrence of DGF and provide an improved acid-base and electrolyte control in patients undergoing kidney transplantation.
Study context
- Population
- Renal transplant patients (perioperative fluid management during kidney transplantation)
- Participants
- 1,668 patients · 12 randomized controlled trials (RCTs)
- Comparison
- Balanced crystalloids vs normal saline
- Balanced crystalloidsn = 832
- Outcome
- Delayed graft function (DGF)
Methodological detailstrial sequential analysis, DerSimonian and Laird random-effects models
- Trial sequential analysis
- DerSimonian and Laird random-effects models
Pooled result
DGF
Relative risk
0.82
95% CI 0.71–0.94
P = 0.005
Events by group
Balanced crystalloids vs Normal saline
RR 0.82 (95% CI 0.71–0.94); P = 0.005
As reported in the abstract
Further pooled results
| Outcome | MD (mEq·L −1) (95% CI) | P value | |
|---|---|---|---|
| End-of-surgery chlorideFavored balanced crystalloids | −8.80 (−13.98 to −3.63) | P < 0.001 | |
| Bicarbonate · End of surgeryFavored balanced crystalloids | 2.12 (1.02–3.21) | P < 0.001 | |
| Base excess · End of surgeryFavored balanced crystalloids | 2.41 (0.88–3.95) | P = 0.002 | |
| Potassium · End of surgeryDid not differ between groups | −0.17 (−0.36 to 0.02) | P = 0.07 | |
| −20−10010Difference, mEq·L −1 (linear scale) |
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| pH · End of surgeryFavored balanced crystalloids | 0.06 (0.04–0.07) | P < 0.001 | |
| −0.0500.050.1Difference (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Balanced Crystalloids Versus Normal Saline in Kidney Transplant Patients: An Updated Systematic Review, Meta-analysis, and Trial Sequential Analysis. Anesth Analg. Published 5 April 2024. doi:10.
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