Cardiothoracic & vascular anesthesia
Effects of Balanced Versus Saline-based Solutions on Acute Kidney Injury in Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial
Authors' conclusion
In patients undergoing off-pump bypass surgery with a normal estimated glomerular filtration rate, the intraoperative balanced solution-based chloride-restrictive intravenous fluid administration strategy did not decrease the rate of postoperative acute kidney injury compared with the saline-based chloride-liberal intravenous fluid administration strategy.
Study context
- Population
- Patients undergoing off-pump CABG with normal eGFR, single tertiary care center, June 2014–July 2020
- Participants
- 180 vs 178
- Comparison
- Balanced vs Saline
- Balancedn = 180
- Salinen = 178reference
- Primary endpoint
- AKI (2012 KDIGO Clinical Practice Guideline)
- Follow-up
- Within 7 postoperative days
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Each group vs salineRisk difference (95% CI)
Balanced
−2.86%(−7.72% to 2.01%)
Each group vs salineRelative risk (95% CI)P value
Balanced
0.61(0.26–1.43)
P = 0.35Further findings
- Saline group had higher intraoperative serum chloride and lower base excess, resulting in lower pH, vs balanced group
Original publication
Effects of Balanced Versus Saline-based Solutions on Acute Kidney Injury in Off-pump Coronary Artery Bypass Surgery: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 4 June 2024. doi:10.
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