Cardiothoracic & vascular anesthesia
Effect of Esketamine on Postoperative Delirium and Inflammatory Response in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Study
Primary resultResult — go to the resultRelative risk 0.474 95% CI 0.231–0.970Authors' conclusion
Esketamine can decrease the incidence of POD, reduce postoperative inflammatory levels, and alleviate short-term inflammatory responses in OPCAB patients.
Study context
- Population
- Adults undergoing elective off-pump coronary artery bypass grafting (OPCAB)
- Participants
- 140 adults
- Comparison
- Intraoperative esketamine infusion vs saline placebo
- Primary endpoint
- Incidence of postoperative delirium (POD)
- Follow-up
- Within the first 7 days after surgery
Methodological detailsprospective, triple-blind, single tertiary centre
- Prospective
- Triple-blind
- Single tertiary centre
Primary result
As reported in the abstract
Relative risk
0.474
95% CI 0.231–0.970
P = 0.034
Group S vs Group P
RR 0.474 (95% CI 0.231–0.970); P = 0.034
Further findings
IL-6 level · 12th and 72nd postoperative hours
- Significantly lower in Group S than Group P at 12 h (Z = −2.697)
- P = 0.007
- Significantly lower in Group S than Group P at 72 h (Z = −2.022)
- P = 0.043
C-reactive protein level · 72nd postoperative hour
- Significantly lower in Group S (Z = −2.134)
- P = 0.003
Original publication
Effect of Esketamine on Postoperative Delirium and Inflammatory Response in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Randomized Controlled Study. J Cardiothorac Vasc Anesth. Published 10 April 2025. doi:10.
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