Cardiothoracic & vascular anesthesia
Inhaled iloprost in off-pump coronary artery bypass surgery: a randomized controlled trial
Authors' conclusion
Inhaled iloprost showed a neutral effect on hemodynamic parameters, including the CI and pulmonary vascular resistance index, during OPCAB.
Study context
- Population
- Adults with three-vessel coronary artery disease and known risk factors for hemodynamic instability undergoing off-pump coronary artery bypass surgery (OPCAB)
- Participants
- 100 adults
- Comparison
- Iloprost vs Control
- Primary endpoint
- Cardiac index during mechanical constraint (pulmonary artery catheterization)
- Follow-up
- During grafting
Methodological details1:1 allocation, saline-controlled
- 1:1 allocation
- Saline-controlled
Primary result
As reported in the abstract
Cardiac index
- No significant intergroup differences in cardiac index during grafting
- Iloprost vs Control: P = 0.36
Further findings
Mean pulmonary artery pressure · circumflex grafting · significantly lower in the iloprost group
P = 0.01
- Mean pulmonary artery pressure: group-time interaction P = 0.04
Remaining hemodynamic parameters
- Similar between the groups
Original publication
Inhaled iloprost in off-pump coronary artery bypass surgery: a randomized controlled trial. Can J Anaesth. Published 26 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →