Cardiothoracic & vascular anesthesia
Effects of Preoperative Oral Carbohydrates on Insulin Resistance and Postoperative Recovery in Diabetic Patients Undergoing Coronary Artery Bypass Grafting: A Preliminary Prospective, Single-Blinded, Randomized Controlled Trial
Authors' conclusion
Preoperative CHO may attenuate inflammatory and stress responses without increasing perioperative risk in diabetic patients undergoing OPCAB, although its effect IR remains uncertain.
Study context
- Population
- Diabetic patients scheduled for isolated off-pump coronary artery bypass grafting (OPCAB)1:1 randomisation
- Participants
- 62 patients
- Comparison
- Preoperative oral carbohydrates vs routine fasting
- Primary endpoint
- Postoperative insulin resistance (homeostasis model assessment)
Methodological detailsprospective, single-centre, single-blind, preliminary, Enrolled July 8, 2022 to April 28, 2023, large-volume cardiovascular centre
- Prospective
- Single-centre
- Single-blind
- Preliminary
- Enrolled July 8, 2022 to April 28, 2023, large-volume cardiovascular centre
Primary result
As reported in the abstract
Postoperative insulin resistance
- CHO did not significantly improve insulin resistance (IR)
Secondary outcomes
Postoperative inflammatory markers
- Significantly reduced with CHO
Stress response (e.g., serum cortisol)
- Attenuated in CHO, difference not statistically significant
In-hospital clinical outcomes (exploratory)
- Postoperative drainage higher in CHO; no differences in other clinical outcomes
Original publication
Effects of Preoperative Oral Carbohydrates on Insulin Resistance and Postoperative Recovery in Diabetic Patients Undergoing Coronary Artery Bypass Grafting: A Preliminary Prospective, Single-Blinded, Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 5 August 2025. doi:10.
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