Cardiothoracic & vascular anaesthesia
Renoprotective Effects of Dexmedetomidine Versus Dopamine in High-Risk Renal Patients Undergoing Off-Pump Coronary Artery Bypass Grafting:A Prospective, Randomized, Comparative Study
Authors' conclusion
Dexmedetomidine infusion was superior to dopamine in improving urine output and eGFR in high-risk renal patients undergoing OPCAB, although differences in serum creatinine and BUN were not clinically significant.
Study context
- Population
- Adults aged ≥60 years with preexisting moderate renal insufficiency (eGFR <60 mL/min/1.73 m² and/or serum creatinine ≥1.1 mg/dL) and ≥1 additional risk factor (DM, hypertension or LV ejection fraction <45%), scheduled for elective off-pump CABG (OPCAB)no exclusions after randomisation
- Participants
- 105 adults
- Comparison
- Dexmedetomidine vs low-dose dopamine vs normal saline
- Primary endpoint
- Renoprotective effects: urine output, serum creatinine, BUN and eGFR; AKI per AKIN criteria
- Follow-up
- 24 and 48 postoperative hours
Methodological detailsprospective, open-label, parallel-group, single tertiary cardiac centre
- Prospective
- Open-label
- Parallel-group
- Single tertiary cardiac centre
Primary result
As reported in the abstract
Renal function · Days 1 and 2
- Urine output significantly higher in A than B and C
- p < 0.01
- Serum creatinine and blood urea nitrogen (BUN) significantly lower in A than B and C at both time points; absolute differences not clinically significant
- p < 0.05
- eGFR markedly higher in A than B and C
- p < 0.0001
- Patients developing acute kidney injury (AKI) (Acute Kidney Injury Network (AKIN)) or requiring RRT, any group
- 0
Safety
Adverse events, incl. arrhythmias and need for intra-aortic balloon pump
- Comparable across groups
- P = 0.31
Original publication
Renoprotective Effects of Dexmedetomidine Versus Dopamine in High-Risk Renal Patients Undergoing Off-Pump Coronary Artery Bypass Grafting:A Prospective, Randomized, Comparative Study. J Cardiothorac Vasc Anesth. Published 21 August 2026. doi:10.
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