Cardiothoracic & vascular anesthesia
Effect of 5% albumin on endothelial glycocalyx degradation during off-pump coronary artery bypass
Authors' conclusion
Off-pump coronary surgery was associated with significant EG degradation. Yet, intraoperative fluid therapy with 5% albumin could not ameliorate EG degradation when compared with balanced crystalloid solution.
Study context
- Population
- Patients undergoing off-pump coronary artery bypass surgery
- Participants
- 51 vs 53
- Comparison
- Albumin vs Plasma-Lyte
- Albuminn = 51
- Plasma-Lyten = 53reference
- Primary endpoint
- Plasma syndecan-1 concentration (marker of endothelial glycocalyx degradation)
- Follow-up
- After anesthetic induction (baseline), completion of grafting, and sternal closure
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
Syndecan-1 increased vs baseline after completion of grafting, without any intergroup differences
median difference, 116 ng·mL-1; 95% CI, 67 to 184
P < 0.001
Syndecan-1 increased vs baseline after sternal closure, without any intergroup differences
median difference, 57 ng·mL-1; 95% CI, 36 to 80
P < 0.001
Secondary outcomes
Mean, mL
| Outcome | Albumin | Plasma-Lyte | Mean difference (mL) (95% CI) | P value | |
|---|---|---|---|---|---|
| Fluid requirements | 833 (SD 270) | 1,323 (SD 492) | −489 (−643 to −335) | P < 0.001 | |
| −1000−5000500Difference, mL (linear scale) |
Atrial natriuretic peptide (ANP), tumour necrosis factor (TNF)-α and soluble thrombomodulin
- Similar between the two groups
Safety
| Outcome | Median difference (mL) (95% CI) | P value | |
|---|---|---|---|
| Chest tube drainageGreater in the albumin group | 190 (18–276) | P = 0.03 | |
| −2000200400Difference, mL (linear scale) |
Original publication
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