Cardiothoracic & vascular anesthesia
The Potential Role of Albumin in Reducing Cardiac Surgery–Associated Acute Kidney Injury: A Randomized Controlled Trial
Primary resultResult — go to the resultOdds ratio 0.91 95% CI 0.53–1.58Authors' conclusion
Adding albumin to the CPB priming solution did not decrease the incidence of CSA-AKI in patients with normal preoperative renal function.
Study context
- Population
- Adults scheduled for cardiac surgery with cardiopulmonary bypass (CPB), baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m² and left ventricular ejection fraction ≥40%
- Participants
- 248 adults
- Comparison
- Crystalloid plus 4% albumin vs crystalloid alone as CPB priming solution
- Interventionn = 126
- Controln = 122reference
- Primary endpoint
- Incidence of CSA-AKI (Kidney Disease Improving Global Outcomes criteria)
- Follow-up
- Within 5 days postoperatively
Methodological detailsdouble-blind, single-centre
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Odds ratio
0.91
95% CI 0.53–1.58
Events by treatment group
Intervention vs Control
OR 0.91 (95% CI 0.53–1.58)
Further findings
| Outcome | Intervention | Control | OR (95% CI) | |
|---|---|---|---|---|
| CSA-AKI, baseline eGFR 60 to 70 mL/min/1.73 m² (post-hoc subgroup)Trend toward reduced incidence · post-hoc subgroup analysis | 35.7% | 57.6% | 0.41 (0.16–1.03) | |
| 0.10.31310Odds ratio (log scale) |
Cardiac surgery-associated acute kidney injury (CSA-AKI), eGFR greater than 70 mL/min/1.73 m² (post-hoc subgroup)
- Trend not observed
Safety
Need for inotropes or vasoconstrictors, cardiogenic or distributive shock, bleeding, need for transfusion, use of nephrotoxic drugs
- No significant differences between groups
Original publication
The Potential Role of Albumin in Reducing Cardiac Surgery–Associated Acute Kidney Injury: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →