Hemodynamics, fluids & transfusion
Comparative efficacy of balanced crystalloids versus 0.9% saline on delayed graft function and perioperative outcomes in kidney transplantation: a meta-analysis of randomised controlled trials
Pooled result · Delayed graft functionResult — go to the resultRelative risk 0.82 95% CI 0.69–0.98Authors' conclusion
Balanced crystalloid intravenous fluid therapy reduced delayed graft function incidence and maintained more favourable serum chemistry profiles compared with 0.9% saline in patients undergoing kidney transplantation. However, crystalloid type did not significantly influence vasopressor requirements and length of hospital stay.
Study context
- Population
- Adults undergoing kidney transplantation
- Participants
- 1,717 adults · 11 RCTs
- Comparison
- Balanced crystalloids vs 0.9% saline intraoperatively
- Outcome
- Delayed graft function incidence
Methodological detailsrandom-effects model, GRADE
- Random-effects model
- GRADE
Pooled result
Delayed graft function
Relative risk
0.82
95% CI 0.69–0.98
P = 0.01
Balanced fluids vs 0.9% saline
RR 0.82 (95% CI 0.69–0.98); P = 0.01
As reported in the abstract
Further pooled results
Postoperative serum chemistry
- Higher serum pH, higher bicarbonate and lower chloride with balanced crystalloids
Vasopressor requirements, hospital LOS, serum creatinine
- Effects uncertain
Original publication
Comparative efficacy of balanced crystalloids versus 0.9% saline on delayed graft function and perioperative outcomes in kidney transplantation: a meta-analysis of randomised controlled trials. Br J Anaesth. Published 13 September 2024. doi:10.
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