Hemodynamics, fluids & transfusion
Intraoperative use of balanced crystalloids versus 0.9% saline: a systematic review and meta-analysis of randomised controlled studies
Authors' conclusion
Use of balanced crystalloids, compared with saline, in the perioperative setting has an uncertain effect on mortality and need for renal replacement therapy but probably improves postoperative acid-base status.
Study context
- Population
- Adults randomised intraoperatively to balanced fluids or saline
- Participants
- 3,776 adults · 38 RCTs
- Comparison
- Intraoperative balanced crystalloids vs 0.9% saline
- Outcome
- Patient-important outcomes (balanced crystalloids vs saline)
Methodological detailsrandom-effects model, GRADE certainty assessment
- Random-effects model
- GRADE certainty assessment
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Postoperative mortality (longest follow-up)Very low certainty | 1.51 (0.42–5.36) | |
| Postoperative need for RRTVery low certainty | 0.95 (0.56–1.59) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | MD (95% CI) | |
|---|---|---|
| Postoperative serum pHModerate certainty | 0.05 (0.04–0.06) | |
| −0.0500.050.1Difference (linear scale) |
Original publication
Intraoperative use of balanced crystalloids versus 0.9% saline: a systematic review and meta-analysis of randomised controlled studies. Br J Anaesth. Published 15 July 2023. doi:10.
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