Perioperative medicine & outcomes
Prediction of acute kidney injury in the immediate postoperative period following liver resection: a retrospective cohort study
Main finding · AKI within 7 days after surgeryResult — go to the resultRelative risk 1.74 95% CI 1.20–2.50Authors' conclusion
Oliguria in the PACU was associated with AKI within seven days after surgery. We developed predictive models for 7-day AKI following liver resection that had good performance properties.
Study context
- Population
- Patients who underwent elective liver resection
- Participants
- 1,520 patients
- Exposure
- Postanesthesia care unit (PACU) oliguria vs no PACU oliguria
- Outcome
- Occurrence of AKI
- Follow-up
- Within seven days after surgery
Methodological detailsprediction model development and internal validation, LASSO multivariable logistic regression, optimism-corrected performance
- Prediction model development and internal validation
- LASSO multivariable logistic regression
- Optimism-corrected performance
Main finding
AKI within 7 days after surgery
Relative risk
1.74
95% CI 1.20–2.50
PACU oliguria vs No PACU oliguria
RR 1.74 (95% CI 1.20–2.50)
As reported in the abstract
- Incidence of acute kidney injury (AKI) within 7 days after surgery
- 11%
- Prevalence of PACU oliguria
- 11%
Observational data: associations, not effects.
Further findings
Predictive model performance (two candidate predictor sets, 17 and 11 variables)
- Discrimination (AUC), model 1
- 0.775
- Discrimination (AUC), model 2
- 0.766
- Both models: good discrimination and excellent calibration
- PACU urine output increased models' discrimination
- Optimism-corrected
Original publication
Prediction of acute kidney injury in the immediate postoperative period following liver resection: a retrospective cohort study. Can J Anaesth. Published 14 July 2025. doi:10.
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