Respiratory failure & ventilation
Association between ventilation–perfusion matching improvement during initial prone positioning and intensive care unit (ICU) mortality in patients with moderate to severe acute respiratory distress syndrome (ARDS): a prospective two-center study
Authors' conclusion
Improvement in V/Q matching 4 h within the first PP is associated with lower ICU mortality in patients with moderate to severe ARDS.
Study context
- Population
- Patients with moderate to severe ARDS undergoing prone positioning, V/Q assessed by electrical impedance tomography
- Participants
- 77 patients
- Exposure
- V/Q matching responders vs non-responders during first prone positioning
- Respondersn = 46
- Non-respondersn = 31reference
- Outcome
- ICU mortality
Methodological detailstwo-center
- Two-center
Main finding
As reported in the abstract
P = 0.038
Observational data: associations, not effects.
Secondary outcomes
Ventilator-free days · day 28
P = 0.024
Enhanced V/Q matching and mortality (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Enhanced V/Q matchingIndependent protective factor | 0.790 (0.681–0.917) | P = 0.002 | |
| 0.512Odds ratio (log scale) |
V/Q matching during prone positioning (PP) (electrical impedance tomography (EIT))
- Significant improvement in V/Q matching during PP, mainly via reduced dorsal shunt and ventral dead space; partially sustained after resupination
Original publication
Association between ventilation–perfusion matching improvement during initial prone positioning and ICU mortality in patients with moderate to severe ARDS: a prospective two-center study. Ann Intensive Care. Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →