Respiratory failure & ventilation
Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in patients with acute respiratory distress syndrome (ARDS): a prospective observational study
Authors' conclusion
The response to iNO varied. In responders, EIT showed a potential redistribution of lung perfusion toward ventral regions, with reductions in the proportions of only perfused units and unmatched units in the whole lung.
Study context
- Population
- Mechanically ventilated ARDS patients
- Participants
- 30 participants
- Exposure
- Responders vs non-responders to inhaled nitric oxide (iNO)
- Respondersn = 11
- Outcome
- Effects of iNO on ventilation/perfusion mismatch assessed by EIT
- Follow-up
- 30 min and 3 h after iNO initiation
Methodological detailssingle-center, physiological study, All patients initially received 5 ppm iNO; trial lasted 3 h; Electrical impedance tomography (EIT) and clinical parameters at baseline, 30 min and 3 h
- Single-center
- Physiological study
- All patients initially received 5 ppm iNO; trial lasted 3 h; EIT and clinical parameters at baseline, 30 min and 3 h
Main finding
As reported in the abstract
iNO response (≥ 20% increase in PaO2/FiO2 at 30 min) · 30 min
Patients who responded to iNO
36.7%
11/30
Observational data: associations, not effects.
Original publication
Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in patients with ARDS: a prospective observational study. Crit Care. Published 27 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →