Neuroanesthesia & neurocritical care
Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi‐Centre Cohort Study of 1014 Patients
Main finding · Favourable functional outcome (mRS ≤ 2), aCDE vs no aCDEResult — go to the resultAdjusted odds ratio 0.92 95% CI 0.62–1.34Authors' conclusion
An rCDE was not associated with worse functional outcomes. While aCDEs were linked to unfavourable outcomes in unadjusted analyses, these associations were not significant after adjustment, highlighting the complexity of interpreting NIRS in heterogeneous populations.
Study context
- Population
- Adults anaesthetised by six prehospital critical care teams, monitored with near-infrared spectroscopy (NIRS)
- Participants
- 1,014 adults
- Exposure
- Cerebral desaturation events vs none during prehospital anaesthesia
- Relative cerebral desaturation event (rCDE)n = 199
- Absolute cerebral desaturation event (aCDE)n = 182
- Outcome
- Favourable functional outcome (modified Rankin Scale ≤ 2)
- Follow-up
- 30 days
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Favourable functional outcome (mRS ≤ 2), aCDE vs no aCDE
Adjusted odds ratio
0.92
95% CI 0.62–1.34
P = 0.14
Cerebral desaturation events (rCDE, aCDE) vs none during prehospital anaesthesia
adjusted OR 0.92 (95% CI 0.62–1.34); P = 0.14
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| 30-day survival, aCDE vs no aCDE · 46% vs. 58% · adjusted analyses showed no significant associations | P = 0.006 |
| Favourable functional outcome, aCDE vs no aCDE · 1 year31% vs. 41% · adjusted analyses showed no significant associations | P = 0.043 |
- Supraphysiological baseline among rCDE
- 63% · 125 of 199
Original publication
Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi‐Centre Cohort Study of 1014 Patients. Acta Anaesthesiol Scand. Published 8 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →