Perioperative medicine & outcomes
Association of the exclusive use of intraoperative phenylephrine for treatment of hypotension with the risk of acute kidney injury after noncardiac surgery
Authors' conclusion
The exclusive use of intraoperative phenylephrine is associated with an increased risk of postoperative renal injury.
Study context
- Population
- Adults undergoing major noncardiac surgery
- Participants
- 16,306 adults
- Exposure
- Exclusive intraoperative phenylephrine vs no phenylephrine
- Phenylephrinen = 8,221
- No phenylephrinen = 8,085reference
- Outcome
- Postoperative AKI (Kidney Disease Improving Global Outcomes (KDIGO) criteria)
Methodological detailssingle tertiary care university hospital
- Single tertiary care university hospital
Main finding
As reported in the abstract
Postoperative AKI
Phenylephrine vs No phenylephrineOdds ratio (95% CI)P value
Adjusted model
1.325(1.153–1.524)
Unadjusted
1.615(1.522–1.725)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| Postoperative AKI, excluding patients with >1 min post-phenylephrine hypotension (exploratory) | 1.478 (1.245–1.753) | |
| 0.512Odds ratio (log scale) |
Original publication
Association of the exclusive use of intraoperative phenylephrine for treatment of hypotension with the risk of acute kidney injury after noncardiac surgery. Anaesth Crit Care Pain Med. Published 6 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →