Perioperative medicine & outcomes
Comparison of ephedrine and phenylephrine use on postoperative acute kidney injury in elective noncardiac surgery: A retrospective cohort study
Main finding · Postoperative AKIResult — go to the resultOdds ratio 1.27 95% CI 1.09–1.47Authors' conclusion
Intraoperative phenylephrine was associated with a higher risk of developing postoperative AKI than ephedrine in patients who underwent noncardiac surgery.
Study context
- Population
- Adults undergoing elective noncardiac surgery under GA at a single tertiary centre, January 2011–December 2024
- Participants
- 45,144 adults
- Exposure
- Phenylephrine vs Ephedrine
- Phenylephrinen = 4,302
- Ephedrinen = 40,842reference
- Outcome
- Postoperative AKI
- Follow-up
- Within 7 days postoperatively
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
within 7 days
Odds ratio
1.27
95% CI 1.09–1.47
P = 0.002
Phenylephrine vs Ephedrine
OR 1.27 (95% CI 1.09–1.47); P = 0.002
Observational data: associations, not effects.
Further findings
Dose-response, phenylephrine dose and odds of postoperative acute kidney injury (AKI)
- Nonlinear pattern with ceiling effect, plateauing at ≈1.0 μg/kg
Original publication
Comparison of ephedrine and phenylephrine use on postoperative acute kidney injury in elective noncardiac surgery: A retrospective cohort study. J Clin Anesth. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →