Perioperative medicine & outcomes
Association of intraoperative hypotension and cumulative norepinephrine dose with postoperative acute kidney injury in patients having noncardiac surgery: a retrospective cohort analysis
An erratum to this article was published (Br J Anaesth, Jun 2025 ↗)
Authors' conclusion
Both intraoperative hypotension and cumulative intraoperative norepinephrine dose were independently associated with postoperative AKI in patients undergoing noncardiac surgery.
Study context
- Population
- Adult male and female patients who had noncardiac surgery
- Participants
- 38,338 participants
- Exposure
- AKI vs No AKI
- Outcome
- AKI
- Follow-up
- Within the first 7 postoperative days
Methodological detailsadjusted multivariable logistic regression
- Adjusted multivariable logistic regression
Main finding
As reported in the abstract
Association of intraoperative hypotension and cumulative norepinephrine dose with AKI
Estimate (95% CI)P value
Area under a MAP of 65 mm Hg
OR 1.55 per mm Hg∗day(1.17–2.02)
P = 0.002Cumulative intraoperative norepinephrine dose
OR 1.02 per μg kg-1(1.01–1.02)
P < 0.001Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
Area under a MAP of 65 mm Hg
P < 0.001
Cumulative intraoperative norepinephrine dose
P < 0.001
Original publication
Association of intraoperative hypotension and cumulative norepinephrine dose with postoperative acute kidney injury in patients having noncardiac surgery: a retrospective cohort analysis. Br J Anaesth. Published 12 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →