Perioperative medicine & outcomes
Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry
Primary result · AKI within the first 3 days after surgeryResult — go to the resultOdds ratio 1.03 per 10 mmHg*min 95% CI 1.01–1.05Authors' conclusion
Our secondary analysis of the EU HYPROTECT registry shows that, in a contemporary population of noncardiac surgery patients in whom clinicians strove to avoid profound intraoperative hypotension, intraoperative hypotension is independently associated with AKI within the first 3 days after surgery.
Study context
- Population
- Patients undergoing major noncardiac surgery with predictive BP monitoring, EU HYPROTECT registryanalysed
- Participants
- 697 patients
- Comparison
- Area under a mean arterial pressure (MAP) of 65 mmHg and AKI
- Primary endpoint
- AKI
- Follow-up
- Within the first 3 days after surgery
Methodological detailsmulticentre registry
- Multicentre registry
Primary result
AKI within the first 3 days after surgery
Odds ratio
1.03 per 10 mmHg*min
95% CI 1.01–1.05
P < 0.001
Area under a MAP of 65 mmHg
OR 1.03 per 10 mmHg*min (95% CI 1.01–1.05); P < 0.001
Per 10 mmHg*min, as printed
As reported in the abstract
- Patients developing AKI
- 62 of 697 (9%)
Original publication
Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry. J Clin Monit Comput. Published 17 July 2025. doi:10.
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