Association of a single low-dose intraoperative magnesium bolus with postoperative opioid requirements: a multicentre retrospective cohort study
Main findingResult — go to the resultMean difference 0.9 IV MME 95% CI 0.8–1.0Authors' conclusion
Intraoperative administration of a single bolus of 2 g magnesium iv was associated with a negligible change in postoperative opioid consumption and trivial hemodynamic effects.
Study context
- Population
- Adults receiving GA for elective surgery at 14 hospitals in the northeastern US, 2018–2022
- Participants
- 257,206 patient encounters
- Exposure
- Intraoperative magnesium bolus vs no magnesium
- Magnesiumn = 16,233
- Outcome
- Total postoperative opioid consumption (IV MME administered in PACU)
- Follow-up
- PACU period
Methodological detailsmulticentre, adjusted models
- Multicentre
- Adjusted models
Main finding
As reported in the abstract
Mean difference
0.9 IV MME
95% CI 0.8–1.0
P < 0.001
Magnesium vs No magnesium
mean difference 0.9 IV MME (95% CI 0.8–1.0); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Levels of consciousness in postanesthesia care unit (PACU) and PACU recovery time
- No difference observed
Safety
Intraoperative hemodynamics (arterial BP and heart rate) · after magnesium administration
- Arterial BP and heart rate decreased, with gradual return to baseline and small estimated absolute changes
Original publication
Association of a single low-dose intraoperative magnesium bolus with postoperative opioid requirements: a multicentre retrospective cohort study. Can J Anaesth. Published 27 March 2026. doi:10.
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