Association of clonal haematopoiesis with severe postoperative complications in patients undergoing radical oesophagectomy

Wang, H; Yan, H; Chen, W; Tang, H; Pei, Y; Shan, Q; Cang, J; Miao, C; Tan, L; Tan, L

doi:10.1016/j.bja.2023.10.035

Perioperative medicine & outcomes

Association of clonal haematopoiesis with severe postoperative complications in patients undergoing radical oesophagectomy

Br J AnaesthPublished 2 Dec 2023Prospective observational study

Main findingResultOdds ratio 3.63 95% CI 1.37–9.66

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Authors' conclusion

Clonal haematopoiesis was associated with a higher incidence of severe postoperative complications in patients undergoing radical oesophagectomy

Study context

Population: Patients undergoing radical oesophagectomy
Participants: 156 patients

Exposure: Clonal haematopoiesis (CH) carriers vs non-carriers
CHn = 33
Without CHn = 123reference
Outcome: Incidence of severe postoperative complications (Clavien-Dindo classification ≥3)

Methodological detailssingle-centre

Single-centre

Main finding

As reported in the abstract

Odds ratio

3.63

95% CI 1.37–9.66

P = 0.010

Events by group

CH42.4%14 of 33

Without CH22.8%28 of 123

CH vs without CH

OR 3.63 (95% CI 1.37–9.66); P = 0.010

Observational data: associations, not effects.

Secondary outcomes

Pulmonary complications

P = 0.018

CH45.5%

Without CH24.4%

CH prevalence: 21.2% · 33

Original publication

Association of clonal haematopoiesis with severe postoperative complications in patients undergoing radical oesophagectomy. Br J Anaesth. Published 2 December 2023. doi:10.1016/j.bja.2023.10.035

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