Perioperative medicine & outcomes

Intraoperative hypotension during robotic-assisted radical prostatectomy: A randomised controlled trial comparing standard goal-directed fluid therapy with hypotension prediction index-guided goal-directed fluid therapy

Eur J AnaesthesiolPublished Randomised controlled trial

Authors' conclusion

In our study, HPI guidance did not reduce intraoperative hypotension during RARP.

Study context

Population
Patients undergoing robot-assisted radical prostatectomy (RARP) under GA plus single-shot spinal technique, single-centre university hospital, January 2022 to April 2023
Participants
82 patients
Comparison
Goal-directed therapy (GDT) protocol guided by Hypotension Prediction Index (HPI) vs GDT protocol alone
Primary endpoint
Cumulative amount of intraoperative hypotension (time-weighted average of mean arterial pressure (MAP) below 65 mmHg)
Methodological detailsprospective, single-centre
  • Prospective
  • Single-centre

Primary result

As reported in the abstract

TWA-MAP below 65 mmHg
  • No differences in TWA-MAP between the groups

Further findings

Frequency and duration of hypotensive events

No differences between the groups

Fluid infusion and vasoconstrictor administration

Similar in both groups; both maintained stable haemodynamics with minimal hypotension

LOS

No differences between the groups

Safety

Postoperative complications

No differences between the groups

Original publication

Intraoperative hypotension during robotic-assisted radical prostatectomy: A randomised controlled trial comparing standard goal-directed fluid therapy with hypotension prediction index-guided goal-directed fluid therapy. Eur J Anaesthesiol. Published 9 June 2025. doi:10.1097/eja.0000000000002211

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