Association of General Anesthesia for Cesarean Delivery with Postpartum Depression and Suicidality
Main finding · PPD requiring readmission, outpatient visit, or ED visit (incidence per 1000 person-years)Result — go to the resultAdjusted hazard ratio 1.12 95% CI 0.97–1.30Authors' conclusion
Use of GA for cesarean delivery is independently associated with a significantly increased risk of PPD requiring hospitalization and suicidality.
Study context
- Population
- Women who underwent cesarean delivery in New York State, January 2009–December 2017, followed 1 year after discharge
- Participants
- 325,840 women
- Exposure
- General anesthesia (GA) vs neuraxial anesthesia for cesarean delivery
- GAn = 19,513
- Outcome
- PPD requiring readmission, outpatient visit, or emergency department (ED) visit
- Follow-up
- 1 year after discharge
Methodological detailspropensity score matching, overlap propensity score weighting
- Propensity score matching
- Overlap propensity score weighting
Main finding
As reported in the abstract
PPD requiring readmission, outpatient visit, or ED visit (incidence per 1000 person-years)
Adjusted hazard ratio
1.12
95% CI 0.97–1.30
By group
GA vs Neuraxial anesthesia
aHR 1.12 (95% CI 0.97–1.30)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| PPD requiring readmission38% increased risk | 1.38 (1.07–1.77) | |
| Suicidality45% increased risk | 1.45 (1.02–2.05) | |
| 0.512Adjusted hazard ratio (log scale) |
GA rate, overall cohort
- Received GA, 19,513 women
- 6.0% (95% CI, 5.9-6.1)
- GA rate in women with obstetric complications (43,432 [13.3%])
- 9.7% (95% CI, 9.4-10.0)
PPD incidence, overall cohort
- Incidence rate of PPD per 1000 person-years
- 12.8
- PPD requiring hospital readmission
- 24.5%
- Incidence rate with an obstetric complication, per 1000 person-years
- 17.1
Original publication
Association of General Anesthesia for Cesarean Delivery with Postpartum Depression and Suicidality. Anesth Analg. Published 4 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →