Perioperative medicine & outcomes
Association of Intraoperative End-Tidal CO₂, Ventilation, and Hypotension With Postoperative Mortality in Noncardiac Surgery: A Retrospective Cohort Study
Main finding · In-hospital mortality by intraoperative ETco₂Result — go to the resultAdjusted odds ratio 1.63 95% CI 1.36–1.86Authors' conclusion
In this large retrospective cohort, low intraoperative ETco₂ was independently associated with increased in-hospital mortality, irrespective of intraoperative hypotension and minute ventilation.
Study context
- Population
- Adults undergoing noncardiac surgery under GA with mechanical ventilation, 2010–2020, tertiary care center
- Participants
- 185,455 adults
- Exposure
- Lower vs higher intraoperative mean ETco₂, adjusted for minute ventilation and hypotension
- Outcome
- In-hospital mortality
Methodological detailssingle tertiary care centre, multivariable logistic regression
- Single tertiary care centre
- Multivariable logistic regression
Main finding
In-hospital mortality by intraoperative ETco₂
Adjusted odds ratio
1.63
95% CI 1.36–1.86
Per 5-mmHg ETco₂ decrease from the median
aOR 1.63 (95% CI 1.36–1.86)
Per 5-mmHg ETco₂ decrease from the median, as printed
As reported in the abstract
- In-hospital mortality, overall cohort
- 0.85%
Observational data: associations, not effects.
Further findings
- Findings robust across sensitivity analyses
Original publication
Association of Intraoperative End-Tidal CO₂, Ventilation, and Hypotension With Postoperative Mortality in Noncardiac Surgery: A Retrospective Cohort Study. Anesthesiology. Published 10 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →