Perioperative medicine & outcomes
Association of intraoperative hypotension and postoperative acute kidney injury after adrenalectomy for pheochromocytoma: a retrospective cohort analysis
Authors' conclusion
We found a significant association between hypotension and postoperative AKI in patients with pheochromocytoma undergoing adrenalectomy in the period after tumor resection.
Study context
- Population
- Patients undergoing elective adrenalectomy for pheochromocytoma, Peking Union Medical College Hospital, 1991–201948 developed acute kidney injury (AKI)
- Participants
- 560 patients
- Exposure
- Intraoperative hypotension and postoperative AKI
- Outcome
- Postoperative AKI
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Postoperative AKI by intraoperative MAP exposure
Odds ratio (95% CI)P value
Time-weighted average MAP, whole operation
1.38(0.95–2.00)
P = 0.087Time-weighted average MAP, before tumor resection
0.83(0.65–1.05)
P = 0.12Time-weighted MAP, after tumor resectionunivariable
3.50 ((2.25, 5.46))
Time-weighted % change from baseline, after tumor resectionunivariable
2.03 ((1.56, 2.66))
Time-weighted MAP, after tumor resectionadjusted for sex, surgical type, estimated blood loss
2.36 ((1.46, 3.80))
Time-weighted % change from baseline, after tumor resectionadjusted for sex, surgical type, estimated blood loss
1.63 ((1.23, 2.17))
Observational data: associations, not effects.
Further findings
Time under MAP thresholds <85, 80, 75, 70 and 65 mmHg
- Prolonged exposure at any threshold associated with increased odds of AKI
Original publication
Association of intraoperative hypotension and postoperative acute kidney injury after adrenalectomy for pheochromocytoma: a retrospective cohort analysis. Perioper Med (Lond). Published 16 May 2023. doi:10.
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