Perioperative medicine & outcomes

Association of Intraoperative Occult Hypoxemia With 30-Day and 1-Year Mortality

Anesth AnalgPublished Retrospective cohort study

Authors' conclusion

Intraoperative occult hypoxemic events are associated with significantly higher odds of 30-day and 1-year mortality, independent of self-reported race/ethnicity.

Study context

Population
Adults (≥18 years) undergoing anesthesia 2008–2019 with at least 1 intraoperative arterial blood gas62,707 paired readings
Participants
25,234 adults
Exposure
At least 1 intraoperative occult hypoxemic event vs none
  • At least 1 occult hypoxemic eventn = 351
Outcome
30-day and 1-year postoperative mortality
Follow-up
30 days and 1 year
Methodological detailssingle-centre, propensity score overlap-weighted
  • Single-centre
  • Propensity score overlap-weighted

Main finding

As reported in the abstract

At least 1 occult hypoxemic event vs No occult hypoxemic eventEstimate (95% CI)P value
30-day mortality
OR 2.89(1.46–5.72)
P = 0.002
1-year mortality
HR 1.90(1.48–2.43)
P < 0.001

Observational data: associations, not effects.

Further findings

Interaction of occult hypoxemia with self-reported race/ethnicity

No significant interaction for predicting mortality

Original publication

Association of Intraoperative Occult Hypoxemia With 30-Day and 1-Year Mortality. Anesth Analg. Published 4 February 2025. doi:10.1213/ane.0000000000007405

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