Perioperative medicine & outcomes
Association of Liver Fibrosis Fibrosis-4 Score with Perioperative Complications and Mortality: A Retrospective Multicenter Analysis
Authors' conclusion
The FIB-4 score is associated with postoperative mortality and complications in a population without clinically apparent liver disease
Study context
- Population
- Patients undergoing GA, Multicenter Perioperative Outcomes Group dataset, excluding known liver diseases other than MASLD, hepatic failure and alcohol use disorderprimary outcome cohort
- Participants
- 1,325,102 patients
- Exposure
- Inconclusive or elevated vs low-risk FIB-4 category
- Outcome
- Mortality
- Follow-up
- 30 days postoperatively
Methodological detailshistorical cohort, mixed-effects multivariable logistic regression
- Historical cohort
- Mixed-effects multivariable logistic regression
Main finding
As reported in the abstract
Adjusted conditional odds ratio (cOR)
1.533
99.75% CI 1.453–1.616
Inconclusive
Adjusted cOR
3.765
99.75% CI 3.572–3.969
Elevated
Observational data: associations, not effects.
Secondary outcomes
| Outcome | cOR (99.75% CI) | |
|---|---|---|
| AKIElevated vs Low-risk | 1.515 (1.435–1.598) | |
| Myocardial injuryElevated vs Low-risk | 1.657 (1.401–1.960) | |
| PPCsElevated vs Low-risk | 1.323 (1.280–1.369) | |
| 0.512Conditional odds ratio (log scale) |
Mortality, age-adjusted FIB-4 cutoffs by age category (sensitivity analysis)
- Association persisted
Mortality, FIB-4 as continuous variable
- Dose-response association observed
Original publication
Association of Liver Fibrosis Fibrosis-4 Score with Perioperative Complications and Mortality: A Retrospective Multicenter Analysis. Anesthesiology. Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →