Hemodynamics, fluids & transfusion
Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis
Authors' conclusion
In critically ill patients, escalating doses of noradrenaline correlate with an exponentially rising relative risk of mortality.
Study context
- Population
- Critically ill adults receiving noradrenaline
- Participants
- 29,935 adults · 19 studies
- Comparison
- Mortality by noradrenaline dose
- Outcome
- Mortality
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
Mortality by peak noradrenaline dose (dose-response)
- RR of mortality escalated by a factor of 1.5 per 0.1 µg/kg/min increase in peak noradrenaline dose
- No inflection points in the dose-mortality curve
Further pooled results
Hospital mortality by SOFA-2 noradrenaline category — > 0.4 µg/kg/min vs ≤ 0.2 µg/kg/min · across the three categories
P < 0.001
Original publication
Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis. Crit Care. Published 20 November 2025. doi:10.
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