Performance of closed-loop systems for intravenous drug administration: a systematic review and meta-analysis of randomised controlled trials
Authors' conclusion
Automatic technology may be used to improve the hemodynamic profile during noradrenaline and vasodilators administration and reduce the duration of postanaesthetic recovery.
Study context
- Population
- Adults receiving IV drugs intraoperatively or in the ICU (propofol, noradrenaline, phenylephrine, insulin, neuromuscular blockers, vasodilators)32 studies
- Comparison
- Closed-loop vs manual IV drug administration
- Outcome
- Duration of BP outside prespecified targets
Methodological detailsMost studies at moderate or high risk of bias, Certainty of evidence low or very low for most outcomes
- Most studies at moderate or high risk of bias
- Certainty of evidence low or very low for most outcomes
Pooled result
As reported in the abstract
Closed-loop vs ManualMD (95% CI)
Noradrenaline; I2 = 66.6%
14.9%(9.6–20.2%)
Vasodilators; I2 = 62.3%
7.4%(5.2–9.7%)
Further pooled results
| Outcome | MD (min) (95% CI) | |
|---|---|---|
| Duration of recovery after propofolI2 = 58.6% | 1.3 (0.4–2.1) | |
| Duration of recovery after neuromuscular blockersI2 = 0% | 9.0 (7.9–10.0) | |
| −5051015Difference, min (linear scale) |
Duration of recovery after propofol
- Closed-loop decreased duration of recovery
Duration of recovery after neuromuscular blockers
- Closed-loop decreased duration of recovery
Original publication
Performance of closed-loop systems for intravenous drug administration: a systematic review and meta-analysis of randomised controlled trials. J Clin Monit Comput. Published 11 September 2023. doi:10.
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