Respiratory failure & ventilation
Neuromuscular blockade and oxygenation changes during prone positioning in COVID-19
Main finding · Mean P/F ratio during first prone episodeResult — go to the resultΔmean 47 mmHgAuthors' conclusion
During prone positioning, NMB is associated with increased oxygenation compared to non-NMB therapy, with a sustained effect on return to the supine position.
Study context
- Population
- Invasively ventilated adults with COVID-19 ARDS treated with prone positioning
- Participants
- 220 participants · 548 prone episodes
- Exposure
- NMB vs no NMB during prone positioning
- NMBn = 164
- Outcome
- PaO2:FiO2 (P/F ratio) during prone positioning
- Follow-up
- First prone episode
Main finding
Mean P/F ratio during first prone episode
Δmean
47 mmHg
padj < 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean P/F ratio on return to supine position
Absolute increase from baseline NMB 59 ± 58 mmHg · non-NMB 34 ± 56 mmHg · padj < 0.001
Original publication
Neuromuscular blockade and oxygenation changes during prone positioning in COVID-19. J Crit Care. Published 21 November 2023. doi:10.
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