Respiratory failure & ventilation
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome
Authors' conclusion
These findings suggest that the mortality benefit of NMB varies with baseline Ers.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS)
- Comparison
- Early neuromuscular blockade (NMB) vs no early NMB; effect moderation by baseline Ers, ventilatory ratio and plasma biomarkers
Methodological detailsBayesian logistic regression
- Bayesian logistic regression
Primary result
As reported in the abstract
Moderation of NMB effect on 90-day mortality
- Probability of mortality benefit with NMB increased with higher baseline Ers: posterior probability of interaction
- 92%
- Ers interaction OR
- 0.76 (90% CrI 0.59-0.99)
- Ers ⩾2 cm H2O/(ml/kg): posterior probability of benefit
- 96%
- Ers ⩾2 cm H2O/(ml/kg): median absolute risk reduction
- 9% (90% CrI 0.5-17.9)
- Ventilatory ratio: posterior probability of interaction (no meaningful variation)
- 62%
- Receptor for advanced glycation end-products: posterior probability of interaction
- 12%
- Tumor necrosis factor receptor-1: posterior probability of interaction
- 18%
- IL-6: posterior probability of interaction
- 44%
- IL-8: posterior probability of interaction
- 22%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. Published 1 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →