Recovery of the Acute Hypoxic Ventilatory Response after Reversal of a Minimal Neuromuscular Block: A Randomized Controlled Trial in Healthy, Nonobese Volunteers
Authors' conclusion
The AHVR after reversal of a minimal neuromuscular block with sugammadex did not significantly differ with spontaneous recovery of neuromuscular block. However, fewer patients had residual depression of AHVR when sugammadex was used. In all groups, a considerable proportion of patients had residual depression of the AHVR 40 min after recovery.
Study context
- Population
- Healthy, nonobese volunteers with symptomatic NMB from continuous rocuronium infusion27 analysed
- Participants
- 37 participants
- Comparison
- Sugammadex 2 or 4 mg/kg vs spontaneous recovery of NMB
- Primary endpoint
- Recovery of the acute hypoxic ventilatory response (AHVR)
Methodological detailstwo-experiment
- Two-experiment
Primary result
As reported in the abstract
AHVR
Mean difference, l · % -1 · min -1 (95% CI)
Symptomatic NMB vs BaselineAHVR reduced by 32%; mean TOFR 0.42 ± 0.22
−0.22(−0.32 to −0.12)
Disappearance of all symptoms vs BaselineAHVR depressed by 23%
−0.16(−0.28 to −0.04)
Original publication
Recovery of the Acute Hypoxic Ventilatory Response after Reversal of a Minimal Neuromuscular Block: A Randomized Controlled Trial in Healthy, Nonobese Volunteers. Anesthesiology. Published 11 July 2025. doi:10.
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