Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001: A Randomized Controlled Trial
Authors' conclusion
In this pilot study, the authors demonstrated that ENA-001 restored the hypoxic ventilatory response impaired by propofol.
Study context
- Population
- Healthy male and female volunteers receiving propofol infusion (low and high dose; 0.6 and 2.0 µg/ml)12 completed
- Participants
- 14 participants
- Comparison
- Low- and high-dose ENA-001 vs placebo during propofol infusion
- Primary endpoint
- Restoration of the isohypercapnic hypoxic ventilatory response during propofol infusion
Methodological detailsdouble-blind, crossover, pilot study, population pharmacokinetic/pharmacodynamic analysis
- Double-blind
- Crossover
- Pilot study
- Population pharmacokinetic/pharmacodynamic analysis
Primary result
As reported in the abstract
Propofol concentration reducing the hypoxic ventilatory response by 50% (µg/ml)
1.47 ± 0.20
Steady-state ENA-001 concentration increasing the depressed ventilatory response by 50% (µg/ml)
0.51 ± 0.04
ENA-001 concentration required for full reversal of the propofol effect at the propofol concentration reducing the response by 50% (µg/ml)
1
Safety
- No serious adverse events occurred
Original publication
Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001: A Randomized Controlled Trial. Anesthesiology. Published 19 January 2024. doi:10.
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