Respiratory failure & ventilation
Acute effects of esketamine on hypoxic ventilatory response, haemodynamics, and brain function in healthy volunteers
Authors' conclusion
I.V. esketamine up to 1 mg kg-1 does not affect the ventilatory response to hypoxia, but affects haemodynamics and acute brain function.
Study context
- Population
- Healthy subjects
- Participants
- 18 subjects
- Comparison
- Esketamine infusion vs control
- Esketaminen = 18
- Controln = 18reference
- Outcome
- Ventilatory response to 20 min of isocapnic hypoxia (oxygen saturation ∼80%): hypoxic ventilatory response (peak in first 5 min) and sustained hypoxia (at 20 min)
Main finding
As reported in the abstract
- Esketamine had no effect on the isocapnic ventilatory response to acute and sustained hypoxia
Further findings
Isocapnic ventilation, independent of hypoxia
- Small excitatory effect of ketamine on isocapnic ventilation: mean increase in ventilation (95% CI), P<0.0001
- 3.1 (2.4-3.7) L min-1
Haemodynamics (MAP, heart rate)
- Esketamine increased MAP, similarly during normoxia and hypoxia
- +10 mm Hg
- Esketamine increased heart rate, similarly during normoxia and hypoxia
- +10 beats min-1
Acute brain function
- Esketamine increased anxiety and alertness and affected external perception
Safety
Haemodynamics
- MAP increase with esketamine, similar in normoxia and hypoxia
- +10 mm Hg
- Heart rate increase with esketamine, similar in normoxia and hypoxia
- +10 beats min-1
Original publication
Acute effects of esketamine on hypoxic ventilatory response, haemodynamics, and brain function in healthy volunteers. Br J Anaesth. Published 8 November 2024. doi:10.
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