Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers
Primary resultResult — go to the resultMean difference −1.7 L min-1 95% one-sided CI -∞ to 1.6Authors' conclusion
Midazolam co-administered with oxycodone did not decrease hypercapnic ventilation, compared with oxycodone alone, but did affect tidal volume, ventilatory frequency, and resting end-tidal Pco2.
Study context
- Population
- Healthy participantscrossover
- Participants
- 20 participants
- Comparison
- IV midazolam plus oral oxycodone vs oxycodone alone
- Primary endpoint
- Minute ventilation at an end-tidal Pco2 of 7.3 kPa (modified Read rebreathing)
Methodological detailsdouble-blind, four-period crossover
- Double-blind
- Four-period crossover
Primary result
As reported in the abstract
Mean difference
−1.7 L min-1
95% one-sided CI -∞ to 1.6
P = 0.21
By group
Midazolam plus oxycodone vs Oxycodone alone
mean difference −1.7 L min-1 (95% one-sided CI -∞ to 1.6); P = 0.21
Further findings
| Outcome | Midazolam plus oxycodone | Oxycodone alone | Mean difference (kPa) (95% CI) | |
|---|---|---|---|---|
| Resting end-tidal Pco2 | 5.8 kPa | 5.6 kPa | 0.2 (0.0–0.4) | |
| −0.200.20.40.6Difference, kPa (linear scale) |
Fell asleep or snored
- Fell asleep or snored: of 15 participants
Original publication
Effect of midazolam co-administered with oxycodone on ventilation: a randomised clinical trial in healthy volunteers. Br J Anaesth. Published 21 February 2025. doi:10.
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