Perioperative medicine & outcomes
Association of Preoperative Posterior Cingulate Cortex Microstructural Damage With Postoperative Delirium
Authors' conclusion
These results suggest that preoperative latent brain abnormalities within the dorsal PCC may underlie attention/concentration deficits and susceptibility to postoperative delirium, yet these dorsal PCC NODDI abnormalities were not significantly associated with CSF Aβ levels (a measure of brain Amyloid deposition).
Study context
- Population
- Patients aged ≥60 years undergoing non-cardiac/non-intracranial surgery
- Participants
- 110 patients
- Exposure
- Postoperative delirium vs no postoperative delirium
- Deliriumn = 12
- No deliriumn = 98reference
- Outcome
- Preoperative NODDI microstructure (FISO, NDI, ODI) in the dorsal PCC by later postoperative delirium
- Follow-up
- Before surgery
Methodological detailspre- and post-operative Neurite Orientation Dispersion and Density Imaging (NODDI) MRI
- Pre- and post-operative NODDI MRI
Main finding
As reported in the abstract
Preoperative dorsal PCC NODDI metrics
- Increased FISO and decreased neurite density index (NDI) and orientation dispersion index (ODI) in the dorsal posterior cingulate cortex (PCC) in Delirium vs No delirium
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Association of preoperative dorsal PCC NDI with attention/concentration performance | 0.29 (95% CI 0.10–0.50) | P = 0.008 |
| Association of preoperative dorsal PCC ODI with attention/concentration performance | 0.29 (95% CI 0.03–0.44) | P = 0.004 |
- Association of preoperative dorsal PCC NDI with attention/concentration performance: independent of age, education level, and global brain atrophy
- Association of preoperative dorsal PCC ODI with attention/concentration performance: independent of age, education level, and global brain atrophy
Correlation of diffusion metrics with CSF amyloid beta
- Diffusion metrics not correlated with CSF Aβ positivity or levels
Original publication
Association of Preoperative Posterior Cingulate Cortex Microstructural Damage With Postoperative Delirium. Anesth Analg. Published 17 June 2026. doi:10.
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