Cardiothoracic & vascular anesthesia
Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery
Main finding · Postoperative delirium associated with L-HDL-C% at start of CPBResult — go to the resultOdds ratio 0.23 95% CI 0.08–0.66Authors' conclusion
Circulating blood biomarkers during surgery may provide insight into postoperative cognitive outcomes
Study context
- Population
- Patients aged ≥60 years scheduled for major cardiac surgery with cardiopulmonary bypass (CPB)57 with complete cognitive assessments
- Participants
- 65 patients
- Exposure
- Delirium vs no delirium
- Deliriumn = 10
- Outcome
- Serum lipoproteins and other metabolites (before surgery, start and end of CPB, POD 1) and their association with postoperative delirium
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Postoperative delirium associated with L-HDL-C% at start of CPB · start of CPB
Odds ratio
0.23
95% CI 0.08–0.66
L-HDL-C% (per SD increment)
OR 0.23 (95% CI 0.08–0.66)
Per SD increment, as printed
Observational data: associations, not effects.
Further findings
Serum neurofilament light chain · end of CPB
| Outcome | Spearman ρ (95% CI) |
|---|---|
| Serum neurofilament light chain vs L-HDL-C% (correlation) · start of CPB | −0.39 (−0.59 to −0.15) |
- Incidence of postoperative delirium · within 3 days of surgery
- 18% · 10
- Incidence of postoperative delirium: 10 of 57 with complete cognitive assessments
Serum neurofilament light chain · end of CPB
- Significantly higher in subjects who developed delirium
Original publication
Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 1 October 2025. doi:10.
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