Cardiothoracic & vascular anesthesia
Association of Mechanical Energy and Power with Postoperative Pulmonary Complications in Lung Resection Surgery: A Post Hoc Analysis of Randomized Clinical Trial Data
Primary result · ME (J)Result — go to the resultAdjusted odds ratio 1.44 95% CI 1.16–1.80Authors' conclusion
ME and, in cases requiring longer periods of mechanical ventilation, MP were independently associated with postoperative pulmonary complications in thoracic surgery.
Study context
- Population
- Patients undergoing lung resection surgery with OLV, multicentre RCT 2020–20211,055 analysed
- Participants
- 1,170 patients
- Comparison
- Patients with vs without PPCs
- PPCsn = 431
- Primary endpoint
- Association of time-weighted average MP and ME with pulmonary complications
- Follow-up
- Within 7 postoperative days
Methodological detailspost hoc analysis, multivariable logistic regression
- Post hoc analysis
- Multivariable logistic regression
Primary result
ME (J)
Adjusted odds ratio
1.44
95% CI 1.16–1.80
P = 0.001
By group
ME
aOR 1.44 (95% CI 1.16–1.80); P = 0.001
As reported in the abstract
Further findings
Time-weighted average MP (J/min)
P = 0.091
Time-weighted average mechanical power (MP) and PPCs, mechanical ventilation 210 min or greater (subgroup)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Time-weighted average MP | 1.46 (1.11–1.93) | P = 0.007 | |
| 0.512Adjusted odds ratio (log scale) |
Time-weighted average MP (J/min)
- Association between time-weighted average MP and PPCs was time-dependent
Mechanical energy (ME) and MP normalised to predicted body weight or respiratory system compliance
- Normalization did not alter these associations
Original publication
Association of Mechanical Energy and Power with Postoperative Pulmonary Complications in Lung Resection Surgery: A Post Hoc Analysis of Randomized Clinical Trial Data. Anesthesiology. Published 18 December 2023. doi:10.
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