Cardiothoracic & vascular anaesthesia
Effect of salbutamol during one-lung ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled trial
Primary resultResult — go to the resultMean difference 26 95% CI 0–53Authors' conclusion
Selective salbutamol nebulization during OLV improved oxygenation and respiratory mechanics without serious adverse events
Study context
- Population
- Patients with chronic obstructive pulmonary disease (COPD) scheduled for lung resection with one-lung ventilation (OLV)82 analysed
- Participants
- 90 patients
- Comparison
- Salbutamol vs Placebo
- Salbutamoln = 41
- Placebon = 41reference
- Primary endpoint
- Change in PaO2/FIO2 after nebulization
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Mean difference
26
95% CI 0–53
P = 0.03
Salbutamol vs Placebo
mean difference 26 (95% CI 0–53); P = 0.03
Secondary outcomes
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Alveolar dead space | −1.7 (−4.3 to −0.1) | P = 0.04 | |
| −6−4−202Difference (linear scale) |
Preoperative inhaler therapy (subgroup)
- No between-group differences observed
Safety
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Serum potassium | −0.2 (−0.4 to 0.0) | P = 0.01 | |
| −0.6−0.4−0.200.2Difference (linear scale) |
Heart rate
- Heart rate rose transiently without arrhythmia
Original publication
Effect of salbutamol during one-lung ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled trial. Can J Anaesth. Published 26 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →