Cardiothoracic & vascular anesthesia
One-lung ventilation with fixed and variable tidal volumes on oxygenation and pulmonary outcomes: A randomized trial
Authors' conclusion
One-lung ventilation with variable tidal volume does not meaningfully improve intraoperative oxygenation, and does not reduce postoperative pulmonary complications.
Study context
- Population
- Adults having elective open or video-assisted thoracoscopic lung resection under GA128 analysed
- Participants
- 70 vs 70
- Comparison
- OLV with variable vs fixed tidal volumes
- Variablen = 70
- Fixedn = 70reference
- Primary endpoint
- Intraoperative oxygenation
Primary result
As reported in the abstract
Time-weighted average PaO2 during OLV
P < 0.01
Secondary outcomes
| Outcome | Fixed | Variable | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| At least one composite postoperative pulmonary complication | 26% | 17% | 0.67 (0.34–1.31) | P = 0.24 | |
| Atelectasis in the ventilated lung · initial three postoperative days | 20% | 4.7% | 0.24 (0.01–0.8) | P = 0.02 | |
| 0.050.21520Relative risk (log scale) |
Atelectasis in the ventilated lung · initial three postoperative days
- No significant late postoperative differences
Other secondary outcomes (90-day mortality, heart rate, SpO2/FiO2 ratio)
- No other secondary outcomes both statistically significant and clinically meaningful
Original publication
One-lung ventilation with fixed and variable tidal volumes on oxygenation and pulmonary outcomes: A randomized trial. J Clin Anesth. Published 6 April 2024. doi:10.
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