Cardiothoracic & vascular anesthesia
Associations of driving pressure and mechanical power with postoperative pulmonary complications in one-lung ventilated surgery
Authors' conclusion
In this OLV surgery population, a DP-Pplat-limited mechanical ventilation strategy of 15 cmH2O or DP-PIP of 18 cmH2O was associated with lower risk of PPC.
Study context
- Population
- Patients undergoing OLV surgery, October 2004 to May 2023
- Participants
- 3,386 vs 4,951
- Exposure
- Association of time-weighted median dynamic driving pressure (DP) and mechanical power (MP) with postoperative pulmonary complications (PPC)
- Pplatn = 3,386
- PIPn = 4,951
- Outcome
- PPC
Methodological detailsmultivariate logistic regression adjusted for confounders, risk threshold analysis
- Multivariate logistic regression adjusted for confounders
- Risk threshold analysis
Main finding
As reported in the abstract
Association of DP and MP with PPC
Odds ratio (95 % CI)P value
DP-Pplatindependent association
1.047(1.019–1.075)
P < 0.05DP-PIPindependent association
1.036(1.013–1.059)
P < 0.05MP-Pplatnot independently associated
1.033(0.980–1.089)
P = 0.226MP-PIPnot independently associated
1.048(0.992–1.106)
P = 0.092Observational data: associations, not effects.
Further findings
Risk threshold for PPC
- DP-Pplat risk threshold
- 15 cmH2O
- DP-PIP risk threshold
- 18 cmH2O
Original publication
Associations of driving pressure and mechanical power with postoperative pulmonary complications in one-lung ventilated surgery. J Clin Anesth. Published 27 August 2025. doi:10.
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