Association of second antibiotic dose delays on mortality in patients with septic shock
Authors' conclusion
These delays were associated with increased mortality, increased ICU and hospital length of stay.
Study context
- Population
- Patients admitted with septic shock, 4 institutions in western Pennsylvania
- Participants
- 905 patients · 4 institutions
- Exposure
- Delay vs no delay in second antibiotic dose administration
- Delayn = 181
- Outcome
- Mortality
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
P = 0.018
Observational data: associations, not effects.
Further findings
28-day vasopressor-free days · similar medians
In-hospital LOS
P = 0.022
ICU LOS
P = 0.007
- Frequency of second antibiotic dose delay (≥25% of dosing interval)
- 20% · 181
- 28-day vasopressor-free days — Distribution of 28-day vasopressor-free days differed between groups
- Mann-Whitney U = 57,294.5, z = −2.690, p = 0.006
28-day ventilator-free days
- No difference between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of second antibiotic dose delays on mortality in patients with septic shock. J Crit Care. Published 18 July 2024. doi:10.
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