Neuroanesthesia & neurocritical care
Association of Serum Brain-Derived Tau With Clinical Outcome and Longitudinal Change in Patients With Severe Traumatic Brain Injury
Authors' conclusion
This study suggests that serum BD-tau, T-tau, and p-tau231 have differential associations with clinical outcome and 1-year longitudinal change in patients with sTBI.
Study context
- Population
- Patients with severe traumatic brain injury (TBI) at a neurointensive unit, Sahlgrenska University Hospital, Gothenburg, Sweden, 2006–2015
- Participants
- 39 patients
- Exposure
- Unfavorable vs favorable 1-year outcome
- Outcome
- Associations of serum biomarkers (BD-tau, T-tau, p-tau231, NfL) with clinical outcome (GOS) and longitudinal change
- Follow-up
- Up to 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Serum BD-tau, day 0 · day 0
Each group vs favorable outcomeEstimate (95% CI)
Unfavorable outcome
mean difference 115.9 pg/mL(25.7–206.1)
Unfavorable outcome
mean difference (serum T-tau) 60.3 pg/mL(−22.0 to 142.7)
Unfavorable outcome
mean difference (serum p-tau231) 8.3 pg/mL(−6.4 to 23.0)
Unfavorable outcome
mean difference (serum NfL) −5.4 pg/mL(−99.0 to 88.3)
Observational data: associations, not effects.
Further findings
Biomarkers vs outcome, day 7
- Similar results were recorded on day 7
Longitudinal decrease, whole cohort · days 7 and 365
- Brain-derived tau (BD-tau) decrease, day 7 (from 138.6 to 80.1 pg/mL)
- 42.2%
- BD-tau decrease, day 365 (from 138.6 to 9.7 pg/mL)
- 93.0%
- Total tau (T-tau) decrease, day 7 (from 57.3 to 10.6 pg/mL)
- 81.5%
- T-tau decrease, day 365 (from 57.3 to 0.6 pg/mL)
- 99.0%
- p-tau231 decrease, day 7 (from 20.1 to 1.5 pg/mL)
- 92.5%
- p-tau231 decrease, day 365 (from 20.1 to 1.0 pg/mL)
- 95.0%
- NfL increase day 7 vs day 0 (from 86.8 to 308.9 pg/mL)
- 255.9%
- NfL decrease day 365 vs day 7 (from 308.9 to 9.2 pg/mL)
- 97.0%
Longitudinal change by clinical outcome
- T-tau decreased twice as fast as BD-tau in both outcome groups; similar for p-tau231
- Day 365 levels lower than day 7 for BD-tau but not T-tau or p-tau231
Original publication
Association of Serum Brain-Derived Tau With Clinical Outcome and Longitudinal Change in Patients With Severe Traumatic Brain Injury. JAMA Netw Open. Published 3 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →