Association of Short-term Pain and Chronic Pain Intensity With Cardiometabolic Multimorbidity Progression: A Multistate Markov Model Analysis
Authors' conclusion
Our results highlighted reductions in chronic pain may mitigate both the onset and progression of CMM
Study context
- Population
- UK Biobank participants12.8-year median follow-up
- Participants
- 429,145 participants
- Exposure
- Pain intensity levels vs free-of-pain (FOP)
- Outcome
- CMM trajectories: transitions from enrollment to initial cardiometabolic disease (ICMD), to CMM (≥2 of HF, IHD, stroke, T2D), and to death
Methodological detailsUK Biobank, multistate Markov model
- UK Biobank
- Multistate Markov model
Main finding
As reported in the abstract
Transition from ICMD to CMM
Each group vs FOPHazard ratio (95% CI)
CMLP
1.11(1.06–1.17)
CWSP
1.26(1.13–1.42)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Transition from ICMD to mortalitySTP vs FOP | 0.89 (0.82–0.96) | |
| Transition from ICMD to mortalityCSLP vs FOP | 0.88 (0.82–0.95) | |
| Transition from ICMD to mortalityCMLP vs FOP | 0.87 (0.81–0.93) | |
| Transition from enrollment to mortalitySTP vs FOP | 0.94 (0.89–0.98) | |
| 0.512Hazard ratio (log scale) |
Transitions over follow-up (all participants) · 12.8-year median follow-up
- Developed initial cardiometabolic disease (ICMD)
- 13.1% (56,137/429,145)
- Progressed from ICMD to cardiometabolic multimorbidity (CMM)
- 19.6% (10,979/56,137)
- Died
- 5.3% (22,775/429,145)
Disease-specific transitions to CMM
- Influence of pain intensity varied across transitional stages; Chronic multilocation pain (CMLP) and chronic widespread pain (CWSP) heightened risk of conversion from T2D or ischemic heart disease (IHD) to CMM; only CWSP substantially elevated transition risk from heart failure (HF) to CMM
Original publication
Association of Short-term Pain and Chronic Pain Intensity With Cardiometabolic Multimorbidity Progression: A Multistate Markov Model Analysis. Anesth Analg. Published 15 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →