ICU sedation, delirium & recovery
Association of Sublingual Microcirculation Parameters and Capillary Refill Time in the Early Phase of ICU Admission*
Authors' conclusion
In our ICU population, a single-spot prolonged CRT was independently associated with abnormal microcirculation and increased mortality.
Study context
- Population
- Critically ill adults admitted to ICU of a university hospital
- Participants
- 282 adults
- Outcome
- Association between CRT and simultaneous sublingual microcirculation parameters (sidestream dark field imaging)
- Follow-up
- Within 24 hours of ICU admission
Methodological detailspilot, single-centre (university hospital ICU), Measurements at 10.2 ± 5.7 hours after ICU admission
- Pilot
- Single-centre (university hospital ICU)
- Measurements at 10.2 ± 5.7 hours after ICU admission
Main finding
As reported in the abstract
Correlation of CRT with microcirculation parameters
- Microvascular flow index (MFI), r
- −0.4430 (p < 0.001)
- Proportion of perfused vessels, r
- −0.3708 (p < 0.001)
- Heterogeneity index, r
- 0.4378 (p < 0.001)
- Perfused vessel density, r
- −0.1835 (p = 0.0020)
- Total vessel density, no association
- p = 0.9641
- De Backer score, no association
- p = 0.5202
Observational data: associations, not effects.
Further findings
28-day mortality
| OR (95% CI) | P value | ||
|---|---|---|---|
| CRTMultivariable analysis | 1.296 (1.078–1.558) | P = 0.006 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Microvascular flow abnormalities (MFI < 2.6)Multivariable analysis | 1.608 (2.1–10.2) | P < 0.001 |
Subgroups
- Relationship also maintained in subgroups
Microcirculatory abnormalities, 28-day mortality and Sequential Organ Failure Assessment (SOFA) by capillary refill time (CRT)
- More severe with increasing CRT
Original publication
Association of Sublingual Microcirculation Parameters and Capillary Refill Time in the Early Phase of ICU Admission*. Crit Care Med. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →